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Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Mar 16, 2015 · Propofol infusion syndrome (PRIS) is a rare propofol complication, leading to cardiac failure It was first described in critically ill children and in adults with traumatic brain injury Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Need help signing in? Unauthorized use of this application is strictly prohibited May 13, 2021 · Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990 It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients The main presenting Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:3 days ago · The Power Reactor Information System (PRIS), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS
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