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May 13, 2021 · Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990 It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Propofol is widely used to sedate agitated patients in intensive care units However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS) The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation
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